Article: Measurements of protein sequence-structure correlations
Gavin E. Crooks, Jason Wolfe, Steven E. Brenner, Proteins 57(4):804-810 (2004)
Abstract
Correlations between protein structures and amino acid sequences are widely used for protein structure prediction. For example, secondary structure predictors generally use correlations between a secondary structure sequence and corresponding primary structure sequence, whereas threading algorithms and similar tertiary structure predictors typically incorporate interresidue contact potentials. To investigate the relative importance of these sequence-structure interactions, we performed a systematic study of the mutual information between various aspects of protein sequences and structures.
